Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways

MR Milad, SL Rauch - Trends in cognitive sciences, 2012 - cell.com
Obsessive-compulsive disorder (OCD) affects approximately 2–3% of the population and is
characterized by recurrent intrusive thoughts (obsessions) and repetitive behaviors or …

The neural crossroads of psychiatric illness: an emerging target for brain stimulation

J Downar, DM Blumberger, ZJ Daskalakis - Trends in cognitive sciences, 2016 - cell.com
Recent meta-analyses of structural and functional neuroimaging studies are converging on
a collective core of brain regions affected across most psychiatric disorders, centered on the …

[HTML][HTML] Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients

L Carmi, U Alyagon, N Barnea-Ygael, J Zohar, R Dar… - Brain stimulation, 2018 - Elsevier
Abstract Background Obsessive Compulsive Disorder (OCD) is a chronic and disabling
disorder with poor response to pharmacological treatments. Converging evidences suggest …

The triadic model perspective for the study of adolescent motivated behavior

M Ernst - Brain and cognition, 2014 - Elsevier
The triadic neural systems model is a heuristic tool, which was developed with the goal of
providing a framework for neuroscience research into motivated behaviors. Unlike dual …

Error processing and inhibitory control in obsessive-compulsive disorder: a meta-analysis using statistical parametric maps

LJ Norman, SF Taylor, Y Liu, J Radua, Y Chye… - Biological …, 2019 - Elsevier
Background Error processing and inhibitory control enable the adjustment of behaviors to
meet task demands. Functional magnetic resonance imaging studies report brain activation …

Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuit

MR Milad, SC Furtak, JL Greenberg… - JAMA …, 2013 - jamanetwork.com
Importance Obsessive-compulsive disorder (OCD) may be characterized by impaired self-
regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics …

Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder

A Anticevic, S Hu, S Zhang, A Savic, E Billingslea… - Biological …, 2014 - Elsevier
Background Obsessive-compulsive disorder (OCD) is associated with regional hyperactivity
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …

Comparative multimodal meta-analysis of structural and functional brain abnormalities in autism spectrum disorder and obsessive-compulsive disorder

CO Carlisi, LJ Norman, SS Lukito, J Radua… - Biological …, 2017 - Elsevier
Background Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD)
share inhibitory control deficits possibly underlying poor control over stereotyped and …

Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder

ER Stern, KD Fitzgerald, RC Welsh, JL Abelson… - PloS one, 2012 - journals.plos.org
Background Obsessive-compulsive disorder (OCD) is characterized by an excessive focus
on upsetting or disturbing thoughts, feelings, and images that are internally-generated …

Neural basis of impaired safety signaling in obsessive compulsive disorder

AM Apergis-Schoute, CM Gillan… - Proceedings of the …, 2017 - National Acad Sciences
The ability to assign safety to stimuli in the environment is integral to everyday functioning. A
key brain region for this evaluation is the ventromedial prefrontal cortex (vmPFC). To …