Aspects of intercellular and intracellular signaling systems in cell survival, proliferation,
differentiation, chemosensory behavior, and programmed cell death in free-living unicellular …

Bioactivity-guided fractionation of the root extract of Psorothamnus arborescens yielded the
new isoflavone 5, 7, 3 ', 4 '-tetrahydroxy-2 '-(3, 3-dimethylallyl) isoflavone (1a) and the new 2 …

Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei.
To discover new drugs against the disease, one may use drugs in the clinic for other …

We investigated whether there are changes in protein phosphorylation or protein kinase
activities during the life cycle of Leishmania major. Using a kinase renaturation assay, we …

Previous observations suggested a concomitant relationship between the release of the
variant surface glycoprotein (VSG) and the activation of adenylate cyclase in the …

The expression and function of eukaryotic protein kinases is highly regulated, primarily
through transcriptional and post-translational processes. In this report we demonstrate an …

Aims Leishmaniasis, caused by the protozoan parasite poses a significant health burden
globally. With a very few specific drugs, increased drug resistance it is important to look for …

An increasing number of protein kinases (PKs) of parasitic protozoa are being evaluated as
drug targets. Some PK inhibitors display antiproliferative effects on protozoa. We tested …

Cryptocaryon irritans is a highly detrimental parasite in mariculture, causing significant
economic losses to the aquaculture industry of Larimichthys crocea. In recent years, copper …

The cell cycle compartmentalization of specific activities of the protozoan parasite
Trypanosoma brucei has remained unexplored due to the lack of a cell synchronization …