Immunoassays are currently the methods of choice for the measurement of a large panel of
complex and heterogenous molecules owing to full automation, short turnaround time, high …

This chapter reviews how improvements in sensitivity and specificity of thyroid function tests
[total and free thyroid hormones, TSH, thyroid autoantibodies (TRAb, TPOAb and TgAb) and …

Pre-existing antibodies to biotherapeutic drugs have been detected in drug-naïve subjects
for a variety of biotherapeutic modalities. Pre-existing antibodies are immunoglobulins that …

The 2015 9th Workshop on Recent Issues in Bioanalysis (9th WRIB) took place in Miami,
Florida with participation of 600 professionals from pharmaceutical and biopharmaceutical …

Various blood constituents can interfere with immunoassays, usually by binding the Fc
portion of antibodies. Our previously developed assays for intact free prostate-specific …

The aim of the study was to assess RF cross-reactivity to animal antibodies used in
immunoassays, and to test if selected commercial immunoassays are vulnerable to …

Background: Heterophilic antibodies are still an important source of interference in
immunoassays. We have conducted a screening study for interference in a panel of …

The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1
analogs, brought changes in type 2 diabetes treatment options. For better therapeutic …

The invention is directed to methods and devices for reducing interference from heterophile
antibodies in an analyte immunoassay. In one embodiment, the invention is to a method …

Human leukocyte antigen (HLA) donor-specific antibodies are key serum biomarkers for
assessing the outcome of transplanted patients. Measuring their active concentration, ie the …