Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

The solute carrier family 1 (SLC1) includes five high-affinity glutamate transporters, EAAC1,
GLT-1, GLAST, EAAT4 and EAAT5 (SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 …

At excitatory synapses on CA1 pyramidal cells of the hippocampus, a larger quantal content
is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by α-amino-3-hydroxy-5 …

After a brief history of ergot alkaloids and ergotism, this review focuses on the metabolism
and mechanisms of action of the ergot alkaloids. The authors provide models of how these …

Four l‐glutamate neurotransmitter transporters, the three Na+‐dependent GLAST‐1, GLT‐1
and EAAC‐1, and the Cl−‐dependent EAAT‐4, form a new family of structurally related …

Glutamate transporters clear glutamate from the extracellular space by high-affinity binding
and uptake. Factors that regulate glutamate transporter expression and activity can thereby …

Excitatory amino acid transporters (EAATs) are the primary regulators of extracellular
glutamate concentrations in the central nervous system. Among the five known human EAAT …

▪ Abstract As the most predominant excitatory neurotransmitter, glutamate has the potential
to influence the function of most neuronal circuits in the central nervous system. To limit …

The solute carrier family 1 (SLC1) is composed of five high affinity glutamate transporters,
which exhibit the properties of the previously described system XAG−, as well as two Na+ …