Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

It has been speculated for a number of years that Sonic hedgehog (Shh) signaling plays an
important role in adrenal development. Over the past two years several reports have …

Domesticated species have an attenuated behavioral and physiological stress response
compared to their wild counterparts, but the genetic mechanisms underlying this change are …

Context: Patients with 21-hydroxylase deficiency (21-OHD) have been shown to develop
adrenal adenomas and, in males, testicular adrenal rest tumors (TARTs) at a high …

Understanding the genetic basis of phenotypic diversity is a challenge in contemporary
biology. Domestication provides a model for unravelling aspects of the genetic basis of …

Abstract The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is
critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in …

The melanocortin-2-receptor (MC2R), also known as the ACTH receptor, is a critical
component of the hypothalamic–pituitary–adrenal axis. The importance of MC2R in adrenal …

The metabolic syndrome is a cluster of more or less related metabolic and cardiovascular
derangements including visceral obesity, insulin resistance, blood and tissue dislipidemia …

Stress in day-old chickens from commercial hatcheries is associated with problematic
behavior in adult animals. Recently, we developed a new behavioral handling test for day …

The adrenal gland influences a multitude of processes during stress response, but also
potently affects the immune system, glucose metabolism, electrolyte or water homeostasis …