Lupus anticoagulant detection and interpretation in antiphospholipid syndrome

M Efthymiou, ML Bertolaccini, H Cohen - Rheumatology, 2024 - academic.oup.com
Lupus anticoagulant (LA) is a well-established risk factor for the clinical manifestations of
antiphospholipid syndrome (APS). Accurate LA detection is an essential prerequisite for …

Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives

T Foret, V Dufrost, J Lagrange, P Costa… - Current Rheumatology …, 2024 - Springer
Abstract Purpose of the Review Thrombotic risk assessment in antiphospholipid positive
(aPL+) subjects is a major challenge, and the study of in vitro thrombin generation (thrombin …

An update on laboratory detection and interpretation of antiphospholipid antibodies for diagnosis of antiphospholipid syndrome: guidance from the ISTH-SSC …

KMJ Devreese, ML Bertolaccini, DW Branch… - Journal of Thrombosis …, 2024 - Elsevier
Antiphospholipid syndrome (APS) diagnosis is dependent on the accurate detection and
interpretation of antiphospholipid antibodies (aPL). Lupus anticoagulant (LA), anticardiolipin …

A thrombin-driven neural net diagnoses the antiphospholipid syndrome without the need for interruption of anticoagulation

RMW de Laat-Kremers, D Wahl, S Zuily… - Blood …, 2024 - ashpublications.org
Thrombosis is an important manifestation of the antiphospholipid syndrome (APS). The
thrombin generation (TG) test is a global hemostasis assay, and increased TG is associated …

Endogenous thrombin potential and time-dependent thrombin generation parameters are independent risk factors for mortality in the general population

R de Laat-Kremers, S Costanzo, M Roest… - Journal of Thrombosis …, 2024 - Elsevier
Background Thrombin generation (TG) is used as a global test of coagulation and is an
indicator of thrombosis and bleeding risk. Until now, data on the association of TG and …

Low thrombin inactivation capacity is associated with an increased risk of recurrent ischemic events after ischemic stroke at a young age

JP Spiegelenberg, R De Laat-Kremers, M Roest… - Journal of Thrombosis …, 2024 - Elsevier
Background Patients with ischemic stroke at a young age (18-50 years) have an increased
long-term risk of recurrent ischemic events. Hypercoagulability may contribute to this high …

Thrombosis in Antiphospholipid Syndrome: Current Perspectives and Challenges in Laboratory Testing for Antiphospholipid Antibodies

KMJ Devreese - Seminars in Thrombosis and Hemostasis, 2024 - thieme-connect.com
Antiphospholipid syndrome (APS) diagnosis hinges on identifying antiphospholipid
antibodies (aPL). Currently, laboratory testing encompasses lupus anticoagulant (LA) …

Positive antiphospholipid antibodies increase the risk of ischemic stroke in patients with atrial fibrillation

M Hanarz, M Ząbczyk, J Natorska, M Baran… - Journal of Thrombosis …, 2024 - Elsevier
Background Antiphospholipid antibodies (aPL), including lupus anticoagulant, antibodies
against β 2 glycoprotein I (anti-β2GPI), and anticardiolipin (aCL) antibodies are associated …

[HTML][HTML] Antiphospholipid antibody testing

S Sciascia, B Montaruli, M Infantino - Medicina Clínica, 2024 - Elsevier
Antiphospholipid antibodies (aPL) are a family of autoantibodies targeting phospholipid-
binding proteins and are associated with several clinical settings, and most notably define …

Generace trombinu u patofyziologických stavů

I Malíková - 2024 - dspace.cuni.cz
Úvod: Trombofilní stavy mohou být provázeny zvýšenou generací trombinu, zvláště pak v
těhotenství, kdy nárůst generace trombinu vyplývá z řady změn v hemostatickém systému …