[HTML][HTML] The role of Interleukin 6 inhibitors in therapy of severe COVID-19
E Nasonov, M Samsonov - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …
[HTML][HTML] The role of CD4+ FoxP3+ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment
Y Wang, J Zheng, MS Islam, Y Yang… - International journal of …, 2021 - ncbi.nlm.nih.gov
The severe cases of Coronavirus Disease 2019 (COVID-19) frequently exhibit excessive
inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and …
inflammatory responses, acute respiratory distress syndrome (ARDS), coagulopathy, and …
[HTML][HTML] The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review
AG Kaye, R Siegel - PeerJ, 2020 - peerj.com
Background In the absence of highly effective antiviral therapies against SARS-CoV-2, it is
crucial to counter the known pathophysiological causes of severe COVID-19. Evaluating the …
crucial to counter the known pathophysiological causes of severe COVID-19. Evaluating the …
[HTML][HTML] Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?
A Kovalchuk, B Wang, D Li, R Rodriguez-Juarez… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of
proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory …
proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory …
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)
R Elahi, P Karami, AH Heidary… - International …, 2022 - Elsevier
Abstract Since 2019, COVID-19 has become the most important health dilemma around the
world. The dysregulated immune response which results in ARDS and cytokine storm has …
world. The dysregulated immune response which results in ARDS and cytokine storm has …
Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS …
S Cremer, C Jakob, A Berkowitsch, S Borgmann… - Clinical research in …, 2021 - Springer
Aims SARS-CoV-2 infection is associated with adverse outcomes in patients with
cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical …
cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical …
Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trials
A Belletti, C Campochiaro, M Marmiere… - Annals of Intensive …, 2021 - Springer
Purpose COVID-19 is characterized by dysregulated immune response, respiratory failure
and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in …
and a relevant mortality rate among hospitalized patients. Interleukin-6 (IL-6) is involved in …
A missing link: engagements of dendritic cells in the pathogenesis of SARS-CoV-2 infections
A Alamri, D Fisk, D Upreti, SKP Kung - International Journal of Molecular …, 2021 - mdpi.com
Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry
out numerous roles that are significant in the context of viral disease. Their functions include …
out numerous roles that are significant in the context of viral disease. Their functions include …
[HTML][HTML] Early tocilizumab dosing is associated with improved survival in critically ill patients infected with severe acute respiratory syndrome coronavirus-2
RM Petrak, NW Van Hise, NC Skorodin… - Critical Care …, 2021 - journals.lww.com
Objectives: To identify the most efficacious timing for tocilizumab administration in critically ill
patients infected with severe acute respiratory syndrome coronavirus-2. Design …
patients infected with severe acute respiratory syndrome coronavirus-2. Design …
Ac2-26 mimetic peptide of annexin A1 to treat severe COVID-19: A hypothesis
AG Bonavita - Medical Hypotheses, 2020 - Elsevier
Abstract The Coronavirus Diseases-2019 (COVID-19) pandemic leads many researchers
around the world to study the SARS-CoV-s2 infection and pathology to find a treatment for it …
around the world to study the SARS-CoV-s2 infection and pathology to find a treatment for it …