Update on rotavirus vaccine underperformance in low-to middle-income countries and next-generation vaccines

B Lee - Human vaccines & immunotherapeutics, 2021 - Taylor & Francis
In the decade since oral rotavirus vaccines (ORV) were recommended by the World Health
Organization for universal inclusion in all national immunization programs, significant yet …

Vaccines for preventing rotavirus diarrhoea: vaccines in use

H Bergman, N Henschke, D Hungerford… - Cochrane Database …, 2021 - cochranelibrary.com
Background Rotavirus is a common cause of diarrhoea, diarrhoea‐related hospital
admissions, and diarrhoea‐related deaths worldwide. Rotavirus vaccines prequalified by …

[HTML][HTML] Overview of the development, impacts, and challenges of live-attenuated oral rotavirus vaccines

OS Folorunso, OM Sebolai - Vaccines, 2020 - mdpi.com
Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following
the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe …

Nanoparticles for mucosal vaccine delivery

A Thakur, C Foged - Nanoengineered biomaterials for advanced drug …, 2020 - Elsevier
Mucosal surfaces represent important routes of entry into the human body for the majority of
pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle …

[HTML][HTML] Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries

CE Otero, SN Langel, M Blasi, SR Permar - PLoS pathogens, 2020 - journals.plos.org
Rotavirus (RV) vaccine efficacy is significantly reduced in lower-and middle-income
countries (LMICs) compared to high-income countries. This review summarizes current …

[HTML][HTML] A phase III randomized-controlled study of safety and immunogenicity of DTwP-HepB-IPV-Hib vaccine (HEXASIIL®) in infants

H Sharma, S Parekh, P Pujari, S Shewale, S Desai… - npj Vaccines, 2024 - nature.com
A fully liquid hexavalent containing Diphtheria (D), Tetanus (T) toxoids, whole cell Pertussis
(wP), Hepatitis B (Hep B), type 1, 2, 3 of inactivated poliovirus (IPV) and Haemophilus …

Immunogenicity and lot-to-lot consistency of a ready to use liquid bovine-human reassortant pentavalent rotavirus vaccine (ROTASIIL-Liquid) in Indian infants

A Kawade, S Babji, V Kamath, A Raut, CM Kumar… - Vaccine, 2019 - Elsevier
Background A lyophilized bovine-human rotavirus reassortant pentavalent vaccine (BRV-
PV, Rotasiil®) was licensed in 2016. A liquid formulation of this vaccine (LBRV-PV, Rotasiil …

[HTML][HTML] Safety and immunogenicity of human neonatal RV3 rotavirus vaccine (Bio Farma) in adults, children, and neonates in Indonesia: Phase I Trial

JA Thobari, W Damayanti, JH Haposan, H Nirwati… - Vaccine, 2021 - Elsevier
Background Despite safe and effective WHO prequalified rotavirus vaccines, at least 84
million children remain unvaccinated. A birth dose schedule of the RV3-BB vaccine was …

Correlates of immune protection against human rotaviruses: natural infection and vaccination

T Latifi, A Kachooei, S Jalilvand, S Zafarian… - Archives of …, 2024 - Springer
Species A rotaviruses are the leading viral cause of acute gastroenteritis in children under 5
years of age worldwide. Despite progress in the characterization of the pathogenesis and …

Anti-rotavirus antibody measurement in a rotavirus vaccine trial: Choice of vaccine antigen in immunoassays does matter

X Wang, DE Velasquez Portocarrero… - Human Vaccines & …, 2023 - Taylor & Francis
In a clinical trial of Bangladeshi infants who received three doses of RotaTeq (ages 6, 10,
and 14 weeks), we did a head-to-head assessment of two vaccine virus strains to measure …