Three-dimensional cell cultures: the bridge between in vitro and in vivo models
O Urzì, R Gasparro, E Costanzo, A De Luca… - International Journal of …, 2023 - mdpi.com
Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …
in research, providing much fundamental information regarding cellular functions and …
Microphysiological systems: What it takes for community adoption
P Hargrove-Grimes, LA Low… - … Biology and Medicine, 2021 - journals.sagepub.com
Microphysiological systems (MPS) are promising in vitro tools which could substantially
improve the drug development process, particularly for underserved patient populations …
improve the drug development process, particularly for underserved patient populations …
Microphysiological systems evaluation: experience of TEX-VAL tissue chip testing consortium
Much has been written and said about the promise and excitement of microphysiological
systems, miniature devices that aim to recreate aspects of human physiology on a chip. The …
systems, miniature devices that aim to recreate aspects of human physiology on a chip. The …
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs
Angiogenesis is a complex process that is required for development and tissue regeneration
and it may be affected by many pathological conditions. Chemicals and drugs can impact …
and it may be affected by many pathological conditions. Chemicals and drugs can impact …
A spheroid model of early and late‐stage osteosarcoma mimicking the divergent relationship between tumor elimination and bone regeneration
Osteosarcoma is the most diagnosed bone tumor in children. The use of tissue engineering
strategies after malignant tumor resection remains a subject of scientific controversy. As a …
strategies after malignant tumor resection remains a subject of scientific controversy. As a …
Investigation of Giant Cell Tumor of Bone and Tissue Engineering Approaches for the Treatment of Giant Cell Tumor of Bone
Primary bone tumors such as Ewing sarcoma, osteosarcoma, and chondrosarcoma,
secondary bone tumors developed from progressive malignancies, and metastasized bone …
secondary bone tumors developed from progressive malignancies, and metastasized bone …
Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions
T Frankenbach-Désor, I Niesner, P Ahmed… - Cancer and Metastasis …, 2025 - Springer
Osteosarcoma is the most common malignant bone tumor, primarily affecting children and
young adults. For these young patients, the current treatment options for osteosarcoma …
young adults. For these young patients, the current treatment options for osteosarcoma …
A vascularized bone-on-a-chip model development via exploring mechanical stimulation for evaluation of fracture healing therapeutics
Bone is the major connective tissue maintaining the structural integrity of the human body.
However, fracture and many skeletal degenerative diseases can compromise this function …
However, fracture and many skeletal degenerative diseases can compromise this function …
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Introdución e obxectivos: A síndrome de Rabson-Mendenhall encádrase dentro das
síndromes de resistencia á insulina extremas e é causado por variantes bialélicas no xene …
síndromes de resistencia á insulina extremas e é causado por variantes bialélicas no xene …