Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …

Myalgic Encephalomyelitis (ME) continues to cause significant morbidity worldwide with an
estimated one million cases in the United States. Hurdles to establishing consensus to …

Objective The precise intervention of K‐Cl cotransporter isoform 2 (KCC2) as a promising
target for drug‐resistant epilepsy remains elusive. Methods Here, we used a CRISPRa …

Background Previous studies indicated the involvement of cholinergic neurons in seizure;
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in …

Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …

Temporal lobe epilepsy (TLE) is the most common type of epilepsy and is often medically
refractory. Previous studies suggest that selective pharmaco-genetic inhibition of pyramidal …

Previously, we developed electroresponsive hydrogel nanoparticles (ERHNPs) modified
with angiopep-2 (ANG) to facilitate the delivery of the antiseizure drug phenytoin sodium …

High-frequency stimulation (HFS) of the anterior nucleus of thalamus (ANT) is a new and
alternative option for the treatment of intractable epilepsy. However, the responder rate is …

Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …