Targeting neuroinflammation to treat Alzheimer's disease
A Ardura-Fabregat, E Boddeke, A Boza-Serrano… - CNS drugs, 2017 - Springer
Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
Chronic stress, cognitive functioning and mental health
This review aims to discuss the evidence supporting the link between chronic stress,
cognitive function and mental health. Over the years, the associations between these …
cognitive function and mental health. Over the years, the associations between these …
[HTML][HTML] Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …
Vascular hippocampal plasticity after aerobic exercise in older adults
Aerobic exercise in young adults can induce vascular plasticity in the hippocampus, a critical
region for recall and recognition memory. In a mechanistic proof-of-concept intervention over …
region for recall and recognition memory. In a mechanistic proof-of-concept intervention over …
What did you do yesterday? A meta-analysis of sex differences in episodic memory.
To remember what one did yesterday is an example of an everyday episodic memory task,
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
HPA axis and aging in depression: systematic review and meta-analysis
MB Murri, C Pariante, V Mondelli, M Masotti… - …, 2014 - Elsevier
One of the most consistent findings in the biology of depression is an altered activity of the
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …
Effects of hydration status on cognitive performance and mood
Although it is well known that water is essential for human homeostasis and survival, only
recently have we begun to understand its role in the maintenance of brain function. Herein …
recently have we begun to understand its role in the maintenance of brain function. Herein …
A lifespan view of anxiety disorders
EJ Lenze, JL Wetherell - Dialogues in clinical neuroscience, 2011 - Taylor & Francis
Neurodevelopmental changes over the lifespan, from childhood through adulthood into old
age, have important implications for the onset, presentation, course, and treatment of anxiety …
age, have important implications for the onset, presentation, course, and treatment of anxiety …
Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2 DM) are highly prevalent aging‐
related diseases associated with significant morbidity and mortality. Some findings in human …
related diseases associated with significant morbidity and mortality. Some findings in human …
Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram
Background Generalized anxiety disorder (GAD) is a common disorder in older adults,
which has been linked to hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in …
which has been linked to hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in …