S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to
Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor …

Human induced pluripotent stem cells (iPSCs) can be differentiated along various neuronal
lineages to generate two-dimensional neuronal cultures as well as three-dimensional brain …

S100A9 is a potential therapeutic target for various disease including prostate cancer,
colorectal cancer, and Alzheimer's disease. However, the sparsity of atomic level data, such …

Amyloid cascade and neuroinflammation are hallmarks of neurodegenerative diseases, and
pro-inflammatory S100A9 protein is central to both of them. Here, we have shown that …

Age-related macular degeneration (AMD) is a complex disease in which inflammation is
implicated as a key factor but the precise molecular mechanisms are poorly understood …

Acetaminophen (APAP) is a widely used antipyretic and analgesic medication, but its
overdose can induce acute liver failure with lack of effective therapies. Icariin is a bioactive …

Traumatic brain injury (TBI) represents a significant risk factor for development of
neurodegenerative diseases such as Alzheimer's and Parkinson's. The S100A9-driven …

Alzheimer's disease (AD) is a multifactorial disease with a complex pathogenesis.
Developing multitarget drugs could be a powerful strategy to impact the progressive loss of …

We studied the effects of chronic intranasal administration of amyloidogenic fibrils of the
proinflammatory protein S100A9 alone or in combination with glutamate antibodies on the …