The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Circulating type I interferon levels and COVID-19 severity: a systematic review and meta-analysis
RP Da Silva, JIB Gonçalves, RF Zanin… - Frontiers in …, 2021 - frontiersin.org
Introduction Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections, resulting in a range of clinical …
syndrome coronavirus 2 (SARS-CoV-2) infections, resulting in a range of clinical …
[HTML][HTML] Serum ferritin at admission in hospitalized COVID-19 patients as a predictor of mortality
K Lino, GMC Guimarães, LS Alves, AC Oliveira… - The Brazilian Journal of …, 2021 - Elsevier
Introduction Some COVID-19 patients have higher mortality and the responsible factors for
this unfavorable outcome is still not well understood. Objective To study the association …
this unfavorable outcome is still not well understood. Objective To study the association …
SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K/AKT pathway
Background SARS-CoV-2 infects through the respiratory route and triggers inflammatory
response by affecting multiple cell types including type II alveolar epithelial cells. SARS-CoV …
response by affecting multiple cell types including type II alveolar epithelial cells. SARS-CoV …
Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study
A Tufa, TH Gebremariam, T Manyazewal… - Frontiers in …, 2022 - frontiersin.org
Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may
represent disease severity. We aimed to assess plasma inflammatory mediator …
represent disease severity. We aimed to assess plasma inflammatory mediator …
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID‐19) severity state
BM Henry, I Szergyuk, MHS de Oliveira… - Journal of medical …, 2021 - Wiley Online Library
Complement system hyperactivation has been proposed as a potential driver of adverse
outcomes in severe acute respiratory syndrome coronavirus 2 infected patients, given prior …
outcomes in severe acute respiratory syndrome coronavirus 2 infected patients, given prior …
Preliminary evidence for IL-10-Induced ACE2 mRNA expression in lung-derived and endothelial cells: implications for SARS-Cov-2 ARDS pathogenesis
Angiotensin-converting enzyme 2 (ACE2) is a receptor for the spike protein of SARS-COV-2
that allows viral binding and entry and is expressed on the surface of several pulmonary and …
that allows viral binding and entry and is expressed on the surface of several pulmonary and …
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
J Sabbatinelli, G Matacchione, A Giuliani… - Mechanisms of Ageing …, 2022 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …
Circulating type I interferon levels in the early phase of COVID-19 are associated with the development of respiratory failure
K Nagaoka, H Kawasuji, Y Murai, M Kaneda… - Frontiers in …, 2022 - frontiersin.org
Background The role of type I interferons (IFNs) in the early phase of COVID-19 remains
unclear. Objectives To evaluate the relationship between IFN-I levels in patients with COVID …
unclear. Objectives To evaluate the relationship between IFN-I levels in patients with COVID …
[HTML][HTML] Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators
Background Severe cases of coronavirus disease 2019 (COVID-19) have increased risk for
acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to …
acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to …