Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to
sudden cardiac death, particularly in young patients and athletes. Pathological features …

Arrhythmogenic right ventricular cardiomyopathy is a heritable heart-muscle disorder that
causes progressive replacement of right ventricular myocardium by fibrofatty tissue …

Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Background—Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a
progressive cardiomyopathy. We aimed to define long-term outcome in a transatlantic cohort …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Understanding the detailed mechanism behind every human disease, disorder, defect, and
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …