Understanding the functional effects of the wide-range of aberrant genetic characteristics
associated with the human chromosome 8q24 region in cancer remains daunting due to the …

Breast cancer is a heterogeneous disease, and risk factors could be differentially associated
with the development of distinct tumor subtypes that manifest different biological behavior …

Genome-wide association studies (GWAS) have successfully identified common
polymorphisms that are strongly associated with many traits, including cancer. A gene desert …

Polymorphisms at 8q24 are robustly associated with prostate cancer risk. The risk variants
are located in nonprotein coding regions and their mechanism has not been fully elucidated …

The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by
promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling …

Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer
regions, serve as a type of critical regulatory element in gene expression. There is …

Background The onset of antibiotics production in Streptomyces species is co-ordinated with
differentiation events. An understanding of the genetic circuits that regulate these coupled …

Inactivation of KLF6 is common in hepatocellular carcinoma (HCC) associated with hepatitis
C virus (HCV) infection, thereby abrogating its normal antiproliferative activity in liver cells …

Recent technological advancements in gene expression analysis have led to the discovery
of a promising new group of prostate cancer (PCa) biomarkers that have the potential to …

Recent genome-wide association studies (GWASs) have identified candidate genes
contributing to cancer risk through low-penetrance mutations. Many of these genes were …