Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Medulloblastoma is an aggressive brain tumor that occurs predominantly in children.
Despite intensive therapy, many patients die of the disease, and novel therapies are …

Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …

Spatially resolved transcriptomics has enabled precise genome-wide mRNA expression
profiling within tissue sections. The performance of methods targeting the polyA tails of …

High myopia is a leading cause of blindness worldwide. Myopia progression may lead to
pathological changes of lens and affect the outcome of lens surgery, but the underlying …

Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four
groups defined by molecular characteristics, Group 3, the least well characterized, is also …

The major cause of treatment failure and mortality among medulloblastoma patients is
metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor …

Medulloblastoma, the most common malignant brain tumor in children, consists of four
molecular subgroups WNT, SHH, Group 3, and Group 4. Group 3 has the worst survival rate …

Multilayer networks allow interpreting the molecular basis of diseases, which is particularly
challenging in rare diseases where the number of cases is small compared with the size of …

Résumé Le médulloblastome est une tumeur maligne cérébrale qui touche principalement
les enfants. Elle est rarement retrouvée chez l'adulte. Parmi les quatre groupes de …