Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the
regulation of lytic and latent viral infection. Like the related proteins expressed by other …

Post-translational modification by members of the small ubiquitin-like modifier (SUMO)
family of proteins is important for the regulation of many cellular proteins and pathways. As …

Chromatin 'readers' are central interpreters of the epigenome that facilitate cell-specific
transcriptional programs and are therapeutic targets in cancer and inflammation. The …

Detection of viral nucleic acids plays a critical role in the induction of intracellular host
immune defences. However, the temporal recruitment of immune regulators to infecting viral …

The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin
ligase ICP0 at early times of infection and is degraded as infection progresses. Here, we …

Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple
mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear factor κB (NF-κB) …

Interferons (IFNs) represent an important host defense against viruses. Type I IFNs induce
JAK-STAT signaling and expression of IFN-stimulated genes (ISGs), which mediate antiviral …

Cellular proteins often have multiple and diverse functions. This is illustrated with protein
Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate …

Human CMV (hCMV) establishes lifelong infections in most of us, causing developmental
defects in human embryos and life-threatening disease in immunocompromised individuals …

Promyelocytic leukemia nuclear bodies (PML NBs) are multi-protein assemblies
representing distinct sub-nuclear structures. As phase-separated molecular condensates …