After a diagnosis of unilateral breast cancer, increasing numbers of patients are requesting
contralateral prophylactic mastectomy (CPM), the surgical removal of the healthy breast after …

Breast cancer is a prevalent malignancy in the present day, particularly affecting women as
one of the most common forms of cancer. A significant portion of patients initially present …

Female breast cancer is the most commonly diagnosed malignancy worldwide. Risk
assessment helps to identify women at increased risk of breast cancer and allows the …

Purpose The field of genetics and genomics continues to expand at an unprecedented pace.
As scientific knowledge is translated to clinical practice, genomic information is routinely …

BRCA1 and BRCA2 are onco-suppressor genes involved in the DNA repair mechanism.
The presence of BRCA1/2 mutations confers a higher risk of developing several cancer …

Simple Summary In this review paper, we focused on the discussion of various important
aspects of hormone receptor (HR)-positive breast cancer, including HR structure and …

Abstract Introduction In the United States, 5%–10% of breast cancer cases are due to
genetic predisposition. Among this population, prophylactic mastectomy is viable risk …

BRCA mutations as a triggering factor in breast cancer have been reported to result in
fertility problems and oocyte aging in young patients with cancer diagnosis. These patients …

Current approach to identify BRCA 1/2 carriers in the general population is ineffective as
most of the carriers remain undiagnosed. Radiomics is an emerging tool for large scale …

Background Risk-reducing mastectomy (RRM) is the most effective breast cancer risk-
reduction strategy in BRCA1/2 mutation carriers. We examined factors associated with RRM …