Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis

KM Wilburn, RA Fieweger… - Pathogens and …, 2018 - academic.oup.com
Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium
tuberculosis, can persist in humans for decades by avoiding clearance from host immunity …

Mycolicibacterium cell factory for the production of steroid-based drug intermediates

A Zhao, X Zhang, Y Li, Z Wang, Y Lv, J Liu… - Biotechnology …, 2021 - Elsevier
Steroid-based drugs have been developed as the second largest medical category in
pharmaceutics. The well-established route of steroid industry includes two steps: the …

A dual role reductase from phytosterols catabolism enables the efficient production of valuable steroid precursors

H Peng, Y Wang, K Jiang, X Chen, W Zhang… - Angewandte …, 2021 - Wiley Online Library
Androstenedione (4‐AD) and progesterone (PG) are two of the most important precursors for
synthesis of steroid drugs, however their current manufacturing processes suffer from low …

Steroids as environmental compounds recalcitrant to degradation: genetic mechanisms of bacterial biodegradation pathways

ER Olivera, JM Luengo - Genes, 2019 - mdpi.com
Steroids are perhydro-1, 2-cyclopentanophenanthrene derivatives that are almost
exclusively synthesised by eukaryotic organisms. Since the start of the Anthropocene, the …

Systematic tracking of nitrogen sources in complex river catchments: Machine learning approach based on microbial metagenomics

Z Zhu, J Ding, R Du, Z Zhang, J Guo, X Li, L Jiang… - Water Research, 2024 - Elsevier
Tracking nitrogen pollution sources is crucial for the effective management of water quality;
however, it is a challenging task due to the complex contaminative scenarios in the …

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent

I Halloum, S Carrère-Kremer, M Blaise… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging
pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer …

Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α2β2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26 …

M Yang, R Lu, KE Guja, MF Wipperman… - ACS infectious …, 2015 - ACS Publications
The metabolism of host cholesterol by Mycobacterium tuberculosis (Mtb) is an important
factor for both its virulence and pathogenesis, although how and why cholesterol …

The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage

BC VanderVen, L Huang, KH Rohde… - Microbiology …, 2016 - Am Soc Microbiol
The interaction between Mycobacterium tuberculosis and its host cell is highly complex and
extremely intimate. Were it not for the disease, one might regard this interaction at the …

[HTML][HTML] Application of microbial 3-ketosteroid Δ1-dehydrogenases in biotechnology

A Rohman, BW Dijkstra - Biotechnology Advances, 2021 - Elsevier
Ketosteroid Δ 1-dehydrogenase catalyzes the 1 (2)-dehydrogenation of 3-ketosteroid
substrates using flavin adenine dinucleotide as a cofactor. The enzyme plays a crucial role …

Degradation of bile acids by soil and water bacteria

FM Feller, J Holert, O Yücel, B Philipp - Microorganisms, 2021 - mdpi.com
Bile acids are surface-active steroid compounds with a C5 carboxylic side chain at the
steroid nucleus. They are produced by vertebrates, mainly functioning as emulsifiers for …