I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

Abstract Purpose of Review The objective of this article is to provide an updated review of
the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and …

Objectives/Hypothesis Establish treatment patterns and economic burden in US patients
with chronic rhinosinusitis with nasal polyposis (CRSwNP) versus without chronic …

Chronic respiratory diseases including chronic rhinosinusitis, otitis media, asthma, cystic
fibrosis, non-CF bronchiectasis, and chronic obstructive pulmonary disease are a major …

Background Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by
persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this …

Chronic rhinosinusitis (CRS) is an inflammatory disease of the sinonasal mucosa. It is likely
due to a dysregulated immune response directed against, and also modified by, antigens …

Objective Both endoscopic sinus surgery (ESS) and biologic therapies have shown
effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) …

Background Appropriate indications for endoscopic sinus surgery (ESS) for chronic
rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical indications for …

Background The role of microbiota in sinonasal inflammation can be further understood by
targeted sampling of healthy and diseased subjects. We compared the microbiota of the …