Food bioactive compounds and emerging techniques for their extraction: Polyphenols as a case study
Experimental studies have provided convincing evidence that food bioactive compounds
(FBCs) have a positive biological impact on human health, exerting protective effects against …
(FBCs) have a positive biological impact on human health, exerting protective effects against …
[HTML][HTML] Unraveling the therapeutic potential of natural products in the prevention and treatment of leukemia
Leukemia is a heterogeneous group of hematological malignancies distinguished by
differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor …
differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor …
Update on the development of MNK inhibitors as therapeutic agents
Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2) represent a central
class of enzymes that are activated by extracellular signal-regulated kinase (ERK) or p38 …
class of enzymes that are activated by extracellular signal-regulated kinase (ERK) or p38 …
Progress in developing MNK inhibitors
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …
MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis
BK Manne, RA Campbell, S Bhatlekar… - Blood, The Journal …, 2022 - ashpublications.org
The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are
phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to …
phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to …
[HTML][HTML] Therapeutic targeting of FLT3 in acute myeloid leukemia: current status and novel approaches
M Tecik, A Adan - OncoTargets and Therapy, 2022 - ncbi.nlm.nih.gov
FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately 30% of acute myeloid
leukemia (AML) patients. The presence of FLT3-ITD (internal tandem duplication, 20–25%) …
leukemia (AML) patients. The presence of FLT3-ITD (internal tandem duplication, 20–25%) …
A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest
C Ferreira, M Sarraguça - Pharmaceuticals, 2024 - mdpi.com
The extraction of bioactive compounds of pharmaceutical interest from natural sources has
been significantly explored in recent decades. However, the extraction techniques used …
been significantly explored in recent decades. However, the extraction techniques used …
The Anticancer Effect of a Flavonoid-Rich Extract of Bergamot Juice in THP-1 Cells Engages the SIRT2/AKT/p53 Pathway
Novel targets are constantly sought to fight hematologic malignancies. In this regard, high
levels of SIRT2 expression are associated with unfavorable prognosis of acute myeloid …
levels of SIRT2 expression are associated with unfavorable prognosis of acute myeloid …
MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation
S Li, J Chen, X Li, D Shi - European Journal of Medicinal Chemistry, 2023 - Elsevier
Overexpression of eIF4E is common in patients with various solid tumors and hematologic
cancers. As a potential anti-cancer target, eIF4E has attracted extensive attention from …
cancers. As a potential anti-cancer target, eIF4E has attracted extensive attention from …
The pro-differentiating capability of a flavonoid-rich extract of Citrus bergamia juice prompts autophagic death in THP-1 cells
L Musumeci, C Russo, U Schumacher… - Scientific Reports, 2024 - nature.com
Acute myeloid leukemia (AML) is a hematologic neoplasm, characterized by a blockage of
differentiation and an unconstrained proliferation of immature myeloid cells. Recently, the …
differentiation and an unconstrained proliferation of immature myeloid cells. Recently, the …