Searches for genes involved in the ageing process have been made in genetically tractable
model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila …

▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

Genome instability, a hallmark of cancer progression, is thought to arise through DNA
double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs …

In eukaryotes, the DNA of the genome is packaged with histone proteins to form
nucleosomal filaments, which are, in turn, folded into a series of less well understood …

Changes to the chromatin structure accompany aging, but the molecular mechanisms
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …

The yeast Sir2 protein, required for transcriptional silencing, has an NAD+-dependent
histone deacetylase (HDA) activity. Yeast extracts contain a NAD+-dependent HDA activity …

Histone methylation is known to be associated with both transcriptionally active and
repressive chromatin states. Recent studies have identified SET domain–containing proteins …

Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …

The trichostatin A (TSA)-sensitive histone deacetylase (HDAC) Rpd3p exists in a complex
with Sin3p and Sap30p in yeast that is recruited to target promoters by transcription factors …

Non-random positioning of chromosomal domains relative to each other and to nuclear
landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA …