Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

An overview of proteases: production, downstream processes and industrial applications

NC Gimenes, E Silveira… - Separation & Purification …, 2021 - Taylor & Francis
Peptidases or proteases are enzymes with the ability to break peptide bonds. They have
been investigated due to their industrial applications in products such as foods and …

Ontogenetic Change in the Venom of Mexican Black-Tailed Rattlesnakes (Crotalus molossus nigrescens)

M Borja, E Neri-Castro, R Pérez-Morales, JL Strickland… - Toxins, 2018 - mdpi.com
Ontogenetic changes in venom composition have important ecological implications due the
relevance of venom in prey acquisition and defense. Additionally, intraspecific venom …

Venom complexity of Bothrops atrox (common lancehead) siblings

DM Hatakeyama, LJ Tasima… - Journal of Venomous …, 2020 - SciELO Brasil
Background: Variability in snake venoms is a well-studied phenomenon. However, sex-
based variation of Bothrops atrox snake venom using siblings is poorly investigated …

State-of-the-art review-A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?

B Kalita, AJ Saviola, SP Samuel… - International Journal of …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent
responsible for the Coronavirus Disease-2019 (COVID-19) pandemic, has infected over 185 …

Venomics and antivenomics of the poorly studied Brazil's lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará

L Sanz, A Pérez, S Quesada-Bernat… - Journal of Venomous …, 2020 - SciELO Brasil
ABSTRACT Background: The Brazil's lancehead, Bothrops brazili, is a poorly studied pit
viper distributed in lowlands of the equatorial rainforests of southern Colombia, northeastern …

Serine proteinases from Bothrops snake venom activates PI3K/Akt mediated angiogenesis

SK Bhat, MB Joshi, A Ullah, R Masood, SG Biligiri… - Toxicon, 2016 - Elsevier
The discovery of rapid acting and powerful angiogenic proteins are of significant interest in
the treatment of various human disorders associated with insufficient angiogenesis such as …

Snake venom, a natural library of new potential therapeutic molecules: Challenges and current perspectives

R Simoes-Silva, J Alfonso, A Gomez… - Current …, 2018 - ingentaconnect.com
Background: Research involving snake venom has gradually surpassed the simple
discovery of new molecules using purification and structural characterization processes, and …

Two-Dimensional Blue Native/SDS Polyacrylamide Gel Electrophoresis for Analysis of Brazilian Bothrops Snake Venoms

N Ferreira de Oliveira, ATA Sachetto, ML Santoro - Toxins, 2022 - mdpi.com
Viperidae snakes are the most important agents of snakebites in Brazil. The protein
composition of snake venoms has been frequently analyzed by means of electrophoretic …

Biological characterization of the Bothrops brazili snake venom and its neutralization by Brazilian Bothrops antivenom produced by the Butantan Institute

EG Muniz, IS Sano-Martins, GS Maria das Graças… - Toxicon, 2023 - Elsevier
We evaluated the ability of the Bothrops antivenom produced by the Butantan Institute to
neutralize the lethal, hemorrhagic, myotoxic and phospholipase A 2 activities induced by B …