Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Improved understanding of the contribution of eosinophils to various chronic inflammatory
conditions, most notably allergic asthma, has encouraged development of monoclonal …

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …

Recent developments in therapeutic strategies have provided alternatives to corticosteroids
as the cornerstone treatment for managing airway inflammation in asthma. The past two …

Eosinophils are potent sources of inflammatory and toxic mediators, yet they reside in large
numbers in the healthy intestine without causing tissue damage. We show here that …

The goal of this series is to offer a survey of the latest literature for clinicians and scientists
alike, providing a list of important recent advances relevant to the broad field of allergy and …

Eosinophils are circulating granulocytes that have pleiotropic effects in response to
inflammatory signals in the body. In response to allergens or pathogens, exposure …

Severe asthma is characterized by different endotypes driven by complex pathologic
mechanisms. In most patients with both allergic and non-allergic asthma, predominant …

Eosinophils are complex granulocytes with the capacity to react upon diverse stimuli due to
their numerous and variable surface receptors, which allows them to respond in very …