Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …

The highly complex and heterogenous ecosystem of a tumour not only contains malignant
cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts …

Inhibitors of the programmed cell death-1 (PD-1/PD-L1) signaling axis are approved to treat
non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) …

A thorough interrogation of the immune landscape is crucial for immunotherapy strategy
selection and prediction of clinical responses in non-small-cell lung cancer (NSCLC) …

There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to
antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells …

Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates whose
formation might be caused by chronic inflammation states, such as cancer. However, how …

Evidence indicates that lung cancer development is a complex process that involves
interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating …

Background Immune infiltration of breast tumours is associated with clinical outcome.
However, past work has not accounted for the diversity of functionally distinct cell types that …

Abstract Purpose: CD8+ tumor-infiltrating lymphocytes (TIL) are key mediators of antitumor
immunity and are strongly associated with survival in virtually all solid tumors. However, the …

Rationale: It is now well established that immune responses can take place outside of
primary and secondary lymphoid organs. We previously described the presence of tertiary …