Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare neurometabolic
disorder caused by disruption of the gamma‐aminobutyric acid (GABA) pathway. A more …

Ischemic stroke is characterized by high morbidity, disability, and mortality. Unfortunately,
the only FDA-approved pharmacological thrombolytic, alteplase, has a narrow therapeutic …

Attempts have been made to use cell transplantation and biomaterials to promote cell
proliferation, differentiation, migration, and survival, as well as angiogenesis, in the context …

Purpose The oxygen and glucose deprivation-reoxygenation (OGDR) model is widely used
to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro …

To date, various agents and molecules have been developed to treat post-stroke
neuroinflammation; however, none of them are clinically successful. Post-stroke …

Abstract Background and Aims Desiccation tolerance (DT) is crucial for survival in arid
environments, where organisms develop strategies in reproduction, maintenance and …

Amyotrophic lateral sclerosis (ALS) leads to death within 2–5 yr. Currently, available drugs
only slightly prolong survival. We present novel insights into the pathophysiology of …

Stroke remains the second leading cause of mortality worldwide, and the third leading cause
of death and morbidity combined, affecting more than 12 million people every year. Stroke …

As the main bioactive component of musk, muscone has been reported to have marked
protective effects in treating acute ischemic stroke (AIS). However, the specific anti-stroke …

The need for advances in the management/treatment options for ischemic stroke patients
requires that upcoming preclinical research uses animals with more human-like brain …