Homologous recombination (HR) is a highly conserved DNA repair mechanism that protects
cells from exogenous and endogenous DNA damage. Breast cancer 1 (BRCA1) and breast …

Background Triple negative breast cancer (TNBC) is a heterogeneous disease with
aggressive behavior and an unfavorable prognosis rate. Due to the lack of surface …

Over the last two decades, numerous BARD1 mutations/pathogenic variants (PVs) have
been found in patients with breast cancer (BC) and ovarian cancer (OC). However, their role …

Breast cancer diagnosed during pregnancy is at increasing incidence due to the increased
frequency of obesity, the postponement of the first pregnancy to later decades of life and the …

Introduction Breast cancer, one of the most aggressive types of cancer, poses significant
challenges for diagnosis and treatment. Emerging as a promising biomarker, circulating …

Ovarian cancer is one of the most frequent malignancies in women. The treatment
landscape underwent significant changes as new agents were introduced in ovarian cancer …

In Romania, breast cancer (BC) is the most common malignancy in women. However, there
is limited data on the prevalence of predisposing germline mutations in the population in the …

Background and study aim Carrying a pathogenic BRCA1/2 variant increases greatly young
women's risk of developing breast cancer (BC). This study aimed to provide the first genetic …

The aim of this study was to identify the frequency and spectrum of germline BRCA1/2
pathogenic alterations in a cohort of patients with breast carcinoma. In this study, a total of …

Population-based estimates of pathogenic variation burden in gynecologic cancer
predisposition genes are a prerequisite for the development of effective precision public …