For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The
specific T cells that mediate tumor rejection are unknown. T cells from human bladder …

Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of
neuroblastoma (NB) patients, but their relationship with other tumor-infiltrating immune cells …

CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a
significant role in the progression of cancer, as well as the course of atherosclerosis, renal …

Spatial transcriptomics seeks to integrate single cell transcriptomic data within the three-
dimensional space of multicellular biology. Current methods to correlate a cell's position with …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive collagen-
rich stroma. T cells that infiltrate pancreatic cancers frequently become trapped in the stroma …

Epstein–Barr virus (EBV) is aetiologically linked to a wide range of human tumours. Some
arise as accidents of the virus' lifestyle in its natural niche, the B lymphoid system; these …

The abundance and type of immune cells in the tumor microenvironment (TME) significantly
influence immunotherapy and tumor progression. However, the role of immune cells in the …