[HTML][HTML] Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma

Y Hoshida, BC Fuchs, N Bardeesy, TF Baumert… - Journal of …, 2014 - Elsevier
Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …

[HTML][HTML] Hepatitis C virus-induced hepatocellular carcinoma

N Goossens, Y Hoshida - Clinical and molecular hepatology, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a leading etiology of hepatocellular carcinoma (HCC). The
interaction of HCV with its human host is complex and multilayered; stemming in part from …

World scientists' warning to humanity: a second notice

WJ Ripple, C Wolf, TM Newsome, M Galetti… - …, 2017 - academic.oup.com
Background. The objective of this study was to determine the efficacy of pegylated interferon
(peg-IFN) plus ribavirin (RBV) in human immunodeficiency virus (HIV)–infected patients with …

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment

P Dongiovanni, QM Anstee… - Current pharmaceutical …, 2013 - ingentaconnect.com
Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver
disease (NAFLD) which, when associated with oxidative hepatocellular damage …

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

M Eslam, AM Hashem, R Leung… - Nature …, 2015 - nature.com
Tissue fibrosis is a core pathologic process that contributes to mortality in~ 45% of the
population and is likely to be influenced by the host genetic architecture. Here we …

[HTML][HTML] Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis

P Nahon, J Zucman-Rossi - Journal of hepatology, 2012 - Elsevier
Liver carcinogenesis is a complex and multi-factorial process, in which both environmental
and genetic features interfere and contribute to malignant transformation. Patients with …

[PDF][PDF] IL28B alleles associated with poor hepatitis C virus (HCV) clearance protect against inflammation and fibrosis in patients infected with non‐1 HCV genotypes

PY Bochud, S Bibert, Z Kutalik, E Patin… - …, 2012 - Wiley Online Library
Genetic polymorphisms near IL28B are associated with spontaneous and treatment‐
induced clearance of hepatitis C virus (HCV), two processes that require the appropriate …

Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus …

CF Huang, ML Yeh, PC Tsai, MH Hsieh, HL Yang… - Journal of …, 2014 - Elsevier
Background & Aims Hepatitis C virus (HCV)-infected patients with cirrhosis remain at risk of
hepatocellular carcinoma (HCC) even after achieving sustained virological response (SVR) …

[PDF][PDF] Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: a longitudinal analysis

M Noureddin, EC Wright, HJ Alter, S Clark… - …, 2013 - Wiley Online Library
Interleukin (IL) 28B polymorphisms are associated with spontaneous clearance of hepatitis
C virus (HCV) infection and response to therapy. Whether IL28B genotype affects fibrosis …

A systematic review of the present and future of non-alcoholic fatty liver disease

C Lucas, G Lucas, N Lucas… - Clinical and …, 2018 - termedia.pl
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the Western world. Ongoing research has furthered our understanding of NAFLD, the …