Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins
and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges …

Despite significant advances in the past two decades, gene therapy is still in the stage of
clinical trials worldwide mainly due to the lack of safe and efficient delivery vehicles for …

Previously, we developed a multifunctional envelope-type nano device (MEND) for efficient
delivery of nucleic acids. For tumor delivery of a MEND, PEGylation is a useful method …

Despite recent progress, systemic delivery remains the major hurdle for development of safe
and effective small inhibitory RNA (siRNA)–based therapeutics. Encapsulation of siRNA into …

For efficient delivery of small interfering RNA (siRNA) in vivo, it is important to control the
blood circulation of the delivery vehicle. Surface modification of the siRNA/cationic liposome …

The manipulation of the RNA interference pathway using small interfering RNA (siRNA) has
become the most frequently used gene silencing method. However, siRNA delivery into …

We have synthesized a series of cationic amino acid-based lipids having a spacer between
the cationic head group and hydrophobic moieties and examined the influence of the spacer …

siRNA has been touted as a therapeutic molecule against genetic diseases, which include
cancers. But several challenging issues remain in order to achieve efficient systemic siRNA …

In our previous study, we have carried out the synthesis of a novel peptide-cationic lipid
(CDO14) for gene delivery. Herein, CDO14 liposome was used for co-delivering resveratrol …

Sequence-non-specific effects of siRNAs that alter the expression of non-targeted genes
have been reported, including competition of siRNAs with endogenous RISC components …