Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

The concept of bioisostere replacement is of paramount importance in medicinal chemistry,
as it can be employed as a rational to expand bioactive chemical space to tackle lead …

As an illicit psychostimulant, repeated methamphetamine (MA) exposure results in addiction
and causes severe neurotoxicity. Studies have revealed complex interactions among gut …

Aims This study evaluated the neurodevelopmental toxicity of isoniazid (INH) in zebrafish
embryos and the underlying mechanism. Methods Zebrafish embryos were exposed to …

The use of psychostimulant drugs can modify brain function by inducing changes in the
reward system, mainly due to alterations in dopaminergic and glutamatergic transmissions …

Methiopropamine is a novel psychoactive substance (NPS) that is associated with several
cases of clinical toxicity, yet little information is available regarding its neuropharmacological …

The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is
increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized …

In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na+,
K+-ATPase ligands, play an integral role in the physiological and pathophysiological …

Bipolar disorder (BD) is a chronic condition characterized by severe mood swings
alternating between episodes of mania and depression. Evidence indicates that protein …

Abstract Methiopropamine or 1-(thiophen-2-yl)-2-methylaminopropane (MPA) is a thiophene
ring-based structural analogue of methamphetamine, first synthesized in 1942 but become …