The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches

A Ahmad, R Ahmad - Saudi Journal of Gastroenterology, 2012 - journals.lww.com
Hepatic fibrosis (HF) is a progressive condition with serious clinical complications arising
from abnormal proliferation and amassing of tough fibrous scar tissue. This defiance of …

Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice

OMS Mostafa, RA Eid, MA Adly - Parasitology Research, 2011 - Springer
The repeated chemotherapy of schistosomiasis has resulted in the emergence of drug-
resistant schistosome strains. The development of such resistance has drawn the attention …

[PDF][PDF] Antischistosomal natural compounds: present challenges for new drug screens

J de Moraes - Current topics in tropical medicine, 2012 - repositorio.utp.edu.co
Schistosomiasis, or bilharzias, is a neglected disease that remains a considerable public
health problem in tropical and subtropical regions. This parasitic disease is the most …

Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection

MM Mantawy, HF Ali, MZ Rizk - … do instituto de medicina tropical de …, 2011 - SciELO Brasil
The effects of both garlic (Allium sativum) and onion (Allium cepa) on some biochemical
parameters in Schistosoma mansoni infected mice individually and mixed either with or …

[HTML][HTML] Ultrastructural study on the morphological changes to male worms of Schistosoma mansoni after in vitro exposure to allicin

CMBL Lima, FIS Freitas, LCSL Morais… - Revista da Sociedade …, 2011 - SciELO Brasil
INTRODUCTION: Garlic has a wide range of actions, including antibacterial, antiviral,
antifungal, antiprotozoal and anthelmintic actions. This antiparasitic activity has been …

[PDF][PDF] Effects of garlic on albino mice experimentally infected with Schistosoma mansoni: a parasitological and ultrastructural study.

NHA Riad, HA Taha, YI Mahmoud - 2009 - academia.edu
Due to increasing problems of the resistance associated with praziquantel, the drug of
choice for treatment of schistosomiasis, alternative therapies are being sought. Scientific …

Parasitological and histopathological studies to the effect of aqueous extract of Moringa oleifera Lam. leaves combined with praziquantel therapy in modulating the liver and …

MI Saad El-Din, HN Gad EL-Hak, MA Ghobashy… - … Science and Pollution …, 2023 - Springer
This study assessed the effectiveness of an aqueous extract of Moringa Oleifera Lam. leaves
(MOL) alone or in combination with praziquantel (PZQ) drug targeting–infected mice with …

[HTML][HTML] Immunomodulatory effect of garlic oil extract on Schistosoma mansoni infected mice

ROA Kamel, NA El-Shinnawy - Asian Pacific journal of tropical medicine, 2015 - Elsevier
Objective To assess the effect potency, and the immunomodulatory response of garlic oil
extract in enhancing the host's immune system against the disorders caused by …

A novel treatment of schistosomiasis: nano-calcium silicate incorporating 5% copper oxide

MF Abou El-Nour, SH Kenawy… - Advanced …, 2020 - pmc.ncbi.nlm.nih.gov
Purpose: Praziquantel (PZQ) is a well-known drug accredited by the World Health
Organization (WHO) for the treatment of schistosomiasis. It shows poor efficiency in patients …