H3Africa: current perspectives

N Mulder, A Abimiku, SN Adebamowo… - Pharmacogenomics …, 2018 - Taylor & Francis
Precision medicine is being enabled in high-income countries by the growing availability of
health data, increasing knowledge of the genetic determinants of disease and variation in …

Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

[PDF][PDF] Environmental microbiology and public health: Advanced strategies for mitigating waterborne and airborne pathogens to prevent disease

AO Olatunji, JA Olaboye, CC Maha… - International Medical …, 2024 - researchgate.net
UV germicidal irradiation, which deactivate pathogens. Enhanced ventilation in buildings
and public spaces also reduces the concentration of airborne pathogens. Public health …

Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project

S Fatumo, A Yakubu, O Oyedele, J Popoola… - Nature Genetics, 2022 - nature.com
To leverage the genetic diversity in Nigeria, we established the Non-Communicable
Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive …

Therapeutic DNA vaccines against HPV-related malignancies: promising leads from clinical trials

J Tang, M Li, C Zhao, D Shen, L Liu, X Zhang, L Wei - Viruses, 2022 - mdpi.com
In 2014 and 2021, two nucleic-acid vaccine candidates named MAV E2 and VGX-3100
completed phase III clinical trials in Mexico and US, respectively, for patients with human …

Taxonomic and functional differences in cervical microbiome associated with cervical cancer development

CN Tango, SS Seo, M Kwon, DO Lee, HK Chang… - Scientific reports, 2020 - nature.com
The cervical microbiome is associated with cervical cancer risk, but how microbial diversity
and functional profiles change in cervical cancer remains unclear. Herein, we investigated …

Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions

S Fatumo, D Sathan, C Samtal, I Isewon, T Tamuhla… - Genome Medicine, 2023 - Springer
Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

[HTML][HTML] Cervical cancer: A meta-analysis, therapy and future of nanomedicine

J Venkatas, M Singh - Ecancermedicalscience, 2020 - ncbi.nlm.nih.gov
Cervical cancer is one of the leading causes of female death, with an annual mortality rate
exceeding 200,000 in developing communities. Despite the past decade bearing witness to …

High-risk HPV genotypes in Zimbabwean women with cervical cancer: Comparative analyses between HIV-negative and HIV-positive women

O Kuguyo, RS Dube Mandishora, NE Thomford… - PLoS …, 2021 - journals.plos.org
Background High-risk human papillomavirus HPV (HR-HPV) modifies cervical cancer risk in
people living with HIV, yet African populations are under-represented. We aimed to compare …

Distinction between vaginal and cervical microbiota in high-risk human papilloma virus-infected women in China

Z Zhang, T Li, D Zhang, X Zong, H Bai, H Bi, Z Liu - Bmc Microbiology, 2021 - Springer
Background High-risk human papilloma virus (hrHPV) is the main causal factor of cervical
precancer and cancer when persistent infection is left untreated. Previous studies have …