BACKGROUND Host immune responses are classically divided into innate immune responses, which react rapidly and nonspecifically upon encountering a pathogen, and …
D Boraschi, P Italiani, S Weil… - Immunological reviews, 2018 - Wiley Online Library
The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …
L Nie, SY Cai, JZ Shao, J Chen - Frontiers in immunology, 2018 - frontiersin.org
The innate immune system is the first line of defense against pathogens, which is initiated by the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼ 500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …
B Gourbal, S Pinaud, GJM Beckers… - Immunological …, 2018 - Wiley Online Library
Over the last decades, there was increasing evidence for the presence of innate immune memory in living organisms. In this review, we compare the innate immune memory of …
Despite the enormous ecological and economic importance of coral reefs, the keystone organisms in their establishment, the scleractinian corals, increasingly face a range of …
Parasites and infectious diseases are everywhere and represent some of the most potent forces shaping the natural world. They affect almost every aspect imaginable in the life of …
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global …
L Franchi, T Eigenbrod, R Muñoz-Planillo… - Nature …, 2009 - nature.com
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …