Current approaches and challenges for the metabolite profiling of complex natural extracts

JL Wolfender, G Marti, A Thomas, S Bertrand - Journal of Chromatography …, 2015 - Elsevier
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …

Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …

JL Wolfender, JM Nuzillard, JJJ Van Der Hooft… - Analytical …, 2018 - ACS Publications
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

T Netzker, J Fischer, J Weber, DJ Mattern… - Frontiers in …, 2015 - frontiersin.org
Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …

Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites

RMK Toghueo - Mycology, 2020 - Taylor & Francis
Endophytic fungi became an attractive source for the discovery of new leads, because of the
complexity and the structural diversity of their secondary metabolites. The genus Fusarium …

Expanding the chemical diversity through microorganisms co-culture: Current status and outlook

D Arora, P Gupta, S Jaglan, C Roullier, O Grovel… - Biotechnology …, 2020 - Elsevier
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

Co-culturing microbial consortia: approaches for applications in biomanufacturing and bioprocessing

RV Kapoore, G Padmaperuma, S Maneein… - Critical Reviews in …, 2022 - Taylor & Francis
The application of microbial co-cultures is now recognized in the fields of biotechnology,
ecology, and medicine. Understanding the biological interactions that govern the …

Strategies to enhance production of metabolites in microbial co-culture systems

L Guo, B Xi, L Lu - Bioresource Technology, 2024 - Elsevier
Increasing evidence shows that microbial synthesis plays an important role in producing
high value-added products. However, microbial monoculture generally hampers metabolites …

Enhancing chemical and biological diversity by co-cultivation

DM Selegato, I Castro-Gamboa - Frontiers in microbiology, 2023 - frontiersin.org
In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …

Plant endophytes and epiphytes: Burgeoning sources of known and “unknown” cytotoxic and antibiotic agents?

DJ Newman, GM Cragg - Planta medica, 2020 - thieme-connect.com
In the last 20 or so years, the influence of endophytes and, quite recently, epiphytes of plants
upon the compounds found in those plants, which were usually assumed to be …

Endophytic and epiphytic microbes as “sources” of bioactive agents

DJ Newman, GM Cragg - Frontiers in chemistry, 2015 - frontiersin.org
Beginning with the report by Stierle and Strobel in 1993 on taxol (R) production by an
endophytic fungus (Stierle et al.,), it is possible that a number of the agents now used as …