The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …

The generation of individual neurons (neurogenesis) during cortical development occurs in
discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis and …

In recent decades, increasing longevity (among other factors) has fostered a rise in
Parkinson's disease incidence. Although not exhaustively studied in this devastating …

Abstract GATAD2B (GATA zinc finger domain containing 2B) variants are associated with
the neurodevelopmental syndrome GAND, characterized by intellectual disability (ID) …

Abstract Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in
many critical cellular pathways, including DNA damage response (DNA repair, cell cycle …

The diverse number of neurons in the cerebral cortex are generated during development by
neural stem cells lining the ventricle, and they continue maturing postnatally. Dynamic …

Protein phosphatase 4 (PP4) is an evolutionarily conserved and essential Ser/Thr
phosphatase that regulates cell division, development and DNA repair in eukaryotes. The …

Glioblastoma multiforme (GBM) heterogeneity causes a greater number of deaths than any
other brain tumor, despite the availability of alkylating chemotherapy. GBM stem-like cells …

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit
(PP4c), which interacts with four different regulatory subunits. Previous studies have shown …

During brain development, the genome must be repeatedly reconfigured in order to facilitate
neuronal and glial differentiation. A host of chromatin remodeling complexes facilitates this …