[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
The role of glial cells in multiple sclerosis disease progression
LM Healy, JA Stratton, T Kuhlmann… - Nature Reviews Neurology, 2022 - nature.com
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …
sclerosis (MS), limited progress has been made in addressing primary progressive or …
Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission …
D Enache, CM Pariante, V Mondelli - Brain, behavior, and immunity, 2019 - Elsevier
Background Increased peripheral inflammation has been consistently reported in patients
with major depressive disorder (MDD). However, only few studies have explored markers of …
with major depressive disorder (MDD). However, only few studies have explored markers of …
[HTML][HTML] Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
PET imaging of neuroinflammation in neurological disorders
A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …
characterise the inflammatory processes underlying various diseases and to inform the …
Neuroinflammation in frontotemporal dementia
Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …
disorders with different pathological signatures, genetic variability and complex disease …
[HTML][HTML] Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders
Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …
involve the activation of microglia and astrocytes. It is a common feature of many central …
Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease
Alzheimer's disease is characterized by the histopathological presence of amyloid-β
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …
plaques and tau-containing neurofibrillary tangles. Microglial activation is also a recognized …
[HTML][HTML] Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …