Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …

Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Future nanoscale soft matter design will be guided to a large extent by the teachings of
amphiphile (lipid or surfactant) self-assembly. Ordered nanostructured lyotropic liquid …

Triterpenes are compounds of natural origin, which have numerously biological activities:
anti-cancer properties, anti-inflammatory, anti-oxidative, anti-viral, anti-bacterial and anti …

Cancer is a community health hazard which progress at a fatal rate in various countries
across the globe. An agent used for chemotherapy should exhibit ideal properties to be an …

Nanomedicine employs nanotechnologies to develop innovative applications, and more
specifically nano-objects in the field of human health, through exploitation of the physical …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

Once introduced in the organism, the interaction of nanoparticles with various biomolecules
strongly impacts their fate. Here we show that nanoparticles made of the squalene derivative …

This study reports the design of a novel theragnostic nanomedicine which combines (i) the
ability to target a prodrug of gemcitabine to an experimental solid tumor under the influence …

Squalene is a triterpene widely distributed in nature that is an intermediate in the cholesterol
biosynthesis pathway. The remarkable dynamic folded conformation of squalene has been …