Idiopathic dilated cardiomyopathy (IDC) is a primary myocardial disease of unknown cause
characterized by left ventricular or biventricular dilatation and impaired myocardial …

Proposed reflex mechanisms for generalized neurohumoral activation in heart failure
include decreased input from inhibitory baroreceptor afferent vessels and increased input …

BACKGROUND In chronic heart failure, the positive inotropic effects of beta-adrenergic
receptor agonists are greatly reduced, in part as a result of two alterations of the cardiac beta …

Background—Heart failure (HF) can occur in patients with preserved (HFpEF, EF≥ 50%) or
reduced (HFrEF, EF< 50%) ejection fraction (EF), but changes in EF after HF diagnosis are …

Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies from
intact nonfailing hearts, and subjects with moderate RV failure from primary pulmonary …

Background Carvedilol has improved the symptomatic status of patients with moderate to
severe heart failure in single-center studies, but its clinical effects have not been evaluated …

BACKGROUND Although heart rate variability (HRV) at 0.1 Hz has been proposed as a
noninvasive clinical measure of cardiac sympathetic nerve firing, this premise has not been …

Background In normal humans, variability of blood pressure, RR interval, and sympathetic
activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency …

Antiadrenergic treatment is currently an emerging and very promising approach to the
treatment of chronic heart failure. Although the adrenergic nervous system can be …

Objective: The alterations in contractile proteins underlying enhanced Ca2+-sensitivity of the
contractile apparatus in end-stage failing human myocardium are still not resolved. In the …