Viral communities in millipede guts: Insights into the diversity and potential role in modulating the microbiome

JE Nweze, JS Schweichhart… - Environmental …, 2024 - Wiley Online Library
Millipedes are important detritivores harbouring a diverse microbiome. Previous research
focused on bacterial and archaeal diversity, while the virome remained neglected. We …

Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project

FF Vale, HpGP Research Network, RJ Roberts… - Gut …, 2024 - Taylor & Francis
Prophages can have major clinical implications through their ability to change pathogenic
bacterial traits. There is limited understanding of the prophage role in ecological …

Genomic characterization of three bacteriophages targeting multidrug resistant clinical isolates of Escherichia, Klebsiella and Salmonella

R Nepal, G Houtak, S Karki, G Dhungana… - Archives of …, 2022 - Springer
Application of bacteriophages (phages) to treat complex multidrug-resistant bacterial
infection is gaining traction because of its efficacy and universal availability. However, as …

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

JM Schröder - Experimental Dermatology, 2024 - Wiley Online Library
The high abundance of Corynebacterium simulans in psoriasis skin suggests a contribution
to the psoriasis aetiology. This hypothesis was tested in an exploratory study, where western …

Directed evolution of bacteriophages: thwarted by prolific prophage

TL Peters, J Schow, E Spencer… - Applied and …, 2024 - journals.asm.org
Various directed evolution methods exist that seek to procure bacteriophages with
expanded host ranges, typically targeting phage-resistant or non-permissive bacterial hosts …

Directed evolution of bacteriophages: impacts of prolific prophage

TL Peters, J Schow, JT Van Leuven, HA Wichman… - bioRxiv, 2024 - biorxiv.org
Various directed evolution methods exist that seek to procure bacteriophages with
expanded host ranges, typically targeting phage-resistant or non-permissive bacterial hosts …

In-silico analysis of probiotic attributes and safety assessment of probiotic strain Bacillus coagulans BCP92 for human application

SS Shaikh, D Jhala, A Patel, S Chettiar… - Letters in Applied …, 2024 - academic.oup.com
The whole genome sequence (WGS) of Bacillus coagulans BCP92 is reported along with its
genomic analysis of probiotics and safety features. The identification of bacterial strain was …

Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coli

G Dhungana, R Nepal, G Houtak, G Bouras… - International …, 2024 - Springer
Phage therapy has recently been revitalized in the West with many successful applications
against multi-drug-resistant bacterial infections. However, the lack of geographically diverse …

Prophage acquisition by Staphylococcus aureus contributes to the expansion of Staphylococcal immune evasion

R Nepal, G Houtak, G Bouras, M Ramezanpour, S Feizi… - bioRxiv, 2023 - biorxiv.org
Staphylococcus aureus colonizes 30% of the human population, but only a few clones
cause severe infections. S. aureus' virulence varies and partly depends on the presence of …

Evidence for the key roles of the Pseudomonas syringae mobilome in shaping biotic interactions

D Holtappels, GEJ Rickus, T Morgan, RR de Rezende… - bioRxiv, 2024 - biorxiv.org
The mobilome, defined as the collection of mobile genetic elements within a bacterial
genome, plays a critical role in the adaptation of bacteria to abiotic and biotic drivers. In …