Mesenchymal stem cell-derived secretome: a potential therapeutic option for autoimmune and immune-mediated inflammatory diseases

G Műzes, F Sipos - Cells, 2022 - mdpi.com
Immune-mediated inflammatory diseases (IMIDs) encompass several entities such as
“classic” autoimmune disorders or immune-mediated diseases with autoinflammatory …

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Engineered Cytokine‐Primed Extracellular Vesicles with High PD‐L1 Expression Ameliorate Type 1 Diabetes

L Wang, C Qi, H Cao, Y Zhang, X Liu, L Qiu, H Wang… - Small, 2023 - Wiley Online Library
Abstract Type 1 diabetes (T1D), which is a chronic autoimmune disease, results from the
destruction of insulin‐producing β cells targeted by autoreactive T cells. The recent …

Tailored extracellular vesicles: novel tool for tissue regeneration

L Li, P Wu, H Qian, W Xu, H Shi… - Stem Cells International, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play an essential part in multiple pathophysiological processes
including tissue injury and regeneration because of their inherent characteristics of small …

[HTML][HTML] Exosomes and microvesicles in kidney transplantation: the long road from trash to gold

L Ramalhete, R Araújo, A Ferreira, CRC Calado - Pathology, 2024 - Elsevier
Kidney transplantation significantly enhances the survival rate and quality of life of patients
with end-stage kidney disease. The ability to predict post-transplantation rejection events in …

Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review …

S Soltani, A Zahedi, AJS Vergara, M Noli… - Stem Cell Reviews and …, 2024 - Springer
Extracellular vesicles isolated from adipose tissue-derived mesenchymal stromal/stem cells
(ADSC-EVs) have demonstrated promising potential in wound healing treatment. To …

[HTML][HTML] Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy

GC Njoku, CP Forkan, FM Soltysik, PL Nejsum… - Bioactive Materials, 2025 - Elsevier
The quality of life for millions of people around the world is severely diminished by the
crippling symptoms of inflammatory bowel diseases (IBD), such as Ulcerative Colitis (UC) …

Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers

I Owliaee, M Khaledian, AK Boroujeni… - Infectious Agents and …, 2023 - Springer
Background Cancer, as a complex, heterogeneous disease, is currently affecting millions of
people worldwide. Even if the most common traditional treatments, namely, chemotherapy …

Small extracellular vesicles as key players in cancer development caused by human oncogenic viruses

S Mahmoudvand, S Shokri, M Nakhaie… - Infectious Agents and …, 2022 - Springer
Background Exosomes are the smallest group of extracellular vesicles in size from 30 to 150
nm, surrounded by a lipid bilayer membrane, and originate from multivesicular bodies …

[HTML][HTML] Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

B Ding, Z Zhu, C Guo, J Li, Y Gan, M Yu - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Diabetes, characterized by hyperglycemia, is a major cause of death and disability
worldwide. Peptides, such as insulin and glucagon-like peptide-1 (GLP-1) analogs, have …