Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022 - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Second near‐infrared photothermal semiconducting polymer nanoadjuvant for enhanced cancer immunotherapy

J Li, X Yu, Y Jiang, S He, Y Zhang, Y Luo… - Advanced …, 2021 - Wiley Online Library
Immunotherapy has offered new treatment options for cancer; however, the therapeutic
benefits are often modest and desired to be improved. A semiconducting polymer …

Improving cancer immunotherapy through nanotechnology

MS Goldberg - Nature Reviews Cancer, 2019 - nature.com
Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

L Chen, H Qin, R Zhao, X Zhao, L Lin, Y Chen… - Science translational …, 2021 - science.org
Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

X Zhao, R Zhao, G Nie - Nature protocols, 2022 - nature.com
Here we present a protocol for the construction and use of two types of nanocarrier based on
bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor …

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing

DR Griffin, MM Archang, CH Kuan, WM Weaver… - Nature materials, 2021 - nature.com
Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked,
microporous scaffolds composed of microgel building blocks and were previously shown to …

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

F Wang, H Su, D Xu, W Dai, W Zhang, Z Wang… - Nature biomedical …, 2020 - nature.com
Tumours with an immunosuppressive microenvironment respond poorly to therapy.
Activation of the stimulator of interferon genes (STING) pathway can enhance intratumoural …

Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis

X Guan, L Sun, Y Shen, F Jin, X Bo, C Zhu… - Nature …, 2022 - nature.com
Cancer recurrence after surgical resection (SR) is a considerable challenge, and the
biological effect of SR on the tumor microenvironment (TME) that is pivotal in determining …