Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs
LM Martínez, J Cruz-Angeles, M Vázquez-Dávila… - Pharmaceutics, 2022 - mdpi.com
Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …
solubility, which affects their bioavailability. In the last two decades, several alternatives …
[HTML][HTML] Cocrystals of tuberculosis antibiotics: Challenges and missed opportunities
E Khanfar, S Nagy, A Széchenyi - International journal of pharmaceutics, 2022 - Elsevier
Cocrystals have been extensively used to improve the physicochemical properties and
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …
Pharmaceutical salts of fenbendazole with organic counterions: structural analysis and solubility performance
AO Surov, NA Vasilev, MV Vener… - Crystal Growth & …, 2021 - ACS Publications
In this work, three new pharmaceutical salts of fenbendazole (FNB), a benzimidazole-based
anthelmintic drug, with sulfonic acids have been obtained and thoroughly investigated by …
anthelmintic drug, with sulfonic acids have been obtained and thoroughly investigated by …
Crystal structure, solubility, and pharmacokinetic study on a hesperetin cocrystal with piperine as coformer
Y Liu, F Yang, X Zhao, S Wang, Q Yang, X Zhang - Pharmaceutics, 2022 - mdpi.com
Hesperetin (HES) is a key biological active ingredient in citrus peels, and is one of the
natural flavonoids that attract the attention of researchers due to its numerous therapeutic …
natural flavonoids that attract the attention of researchers due to its numerous therapeutic …
Simultaneous improvement of dissolution behavior and oral bioavailability of antifungal miconazole via cocrystal and salt formation
Miconazole shows low oral bioavailability in humans due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as antifungal, anti …
although it has demonstrated various pharmacological activities such as antifungal, anti …
[HTML][HTML] A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer
Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in
treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its …
treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its …
[HTML][HTML] Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: An InPharma commentary
Due to the strong tendency towards poorly soluble drugs in modern development pipelines,
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …
enabling drug formulations such as amorphous solid dispersions, cyclodextrins, co-crystals …
In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
Ibrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an
irreversible Bruton's tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral …
irreversible Bruton's tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral …
Pharmaceutical multicomponent crystals of antifungal drugs with improved dissolution performance
New multicomponent crystals of climbazole (CLB) with fumaric acid (FumAc) and
tioconazole (TCL) with oxalic (OxlAc), malonic (MlnAc), fumaric, and dl-tartaric (TartAc) acids …
tioconazole (TCL) with oxalic (OxlAc), malonic (MlnAc), fumaric, and dl-tartaric (TartAc) acids …
[HTML][HTML] Two novel palbociclib-resorcinol and palbociclib-orcinol cocrystals with enhanced solubility and dissolution rate
C Duan, W Liu, Y Tao, F Liang, Y Chen, X Xiao… - Pharmaceutics, 2021 - mdpi.com
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly
restricted due to poor bioavailability (resulting from extremely low water solubility) and …
restricted due to poor bioavailability (resulting from extremely low water solubility) and …