The physiology and genetics of bacterial responses to antibiotic combinations

R Roemhild, T Bollenbach, DI Andersson - Nature Reviews …, 2022 - nature.com
Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Extracellular metabolism sets the table for microbial cross-feeding

RK Fritts, AL McCully, JB McKinlay - Microbiology and Molecular …, 2021 - Am Soc Microbiol
The transfer of nutrients between cells, or cross-feeding, is a ubiquitous feature of microbial
communities with emergent properties that influence our health and orchestrate global …

Putting microbial interactions back into community contexts

EC Pierce, RJ Dutton - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Microbial interactions are increasingly being studied in community
contexts.•Common mechanisms of interaction are found across microbiomes.•Combining …

Valnemulin restores colistin sensitivity against multidrug-resistant gram-negative pathogens

C Xu, Y Zhang, L Ma, G Zhang, C Li, C Zhang… - Communications …, 2024 - nature.com
Colistin is one of the last-resort antibiotics in treating infections caused by multidrug-resistant
(MDR) pathogens. Unfortunately, the emergence of colistin-resistant gram-negative strains …

[HTML][HTML] Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes

SL Bishop, M Drikic, S Wacker, YY Chen… - Mucosal …, 2022 - Elsevier
Advances in technology and software have radically expanded the scope of metabolomics
studies and allow us to monitor a broad transect of central carbon metabolism in routine …

The ecology and evolution of model microbial mutualisms

JM Chacón, SP Hammarlund… - Annual Review of …, 2021 - annualreviews.org
Mutually beneficial interspecific interactions are abundant throughout the natural world,
including between microbes. Mutualisms between microbes are critical for everything from …

[HTML][HTML] Ignoring social distancing: advances in understanding multi-species bacterial interactions

BN Ross, M Whiteley - Faculty Reviews, 2020 - ncbi.nlm.nih.gov
Almost every ecosystem on this planet is teeming with microbial communities made of
diverse bacterial species. At a reductionist view, many of these bacteria form pairwise …

Positive interactions within and between populations decrease the likelihood of evolutionary rescue

Y Goldberg, J Friedman - PLoS Computational Biology, 2021 - journals.plos.org
Positive interactions, including intraspecies cooperation and interspecies mutualisms, play
crucial roles in shaping the structure and function of many ecosystems, ranging from plant …

Reversion to metabolic autonomy underpins evolutionary rescue of a bacterial obligate mutualism

IJ Melero-Jiménez, Y Sorokin, A Merlin, A Couce… - bioRxiv, 2024 - biorxiv.org
Populations facing lethal environmental change can avoid extinction by undergoing rapid
genetic adaptation, a phenomenon termed evolutionary rescue. While this phenomenon has …

[PDF][PDF] The combination of medicinal dyes with conventional antimicrobials: potential for synergy in topical skin infections

R Ramfol - 2023 - wiredspace.wits.ac.za
Medicinal dyes have been used for centuries to treat ailments, however, research into their
use as an antimicrobial has been lacking in recent years and most clinical work predates to …