This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …

Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary
metabolites with many medicinal properties, including the essential anti-cancer therapeutics …

Cofactor-mimetic aerobic oxidation has conceptually merged with catalysis of syngas
reactions to form a wide range of Markovnikov-selective olefin radical …

Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with
marketed pharmaceutical activities against a wide range of indications, including cancer …

Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …

Conspectus While the use of visible light to drive chemical reactivity is of high importance to
the development of environmentally benign chemical transformations, the concomitant use …

Conspectus The implementation of any chemical reaction in a structurally complex setting
(King, SMJ Org. Chem. 2014, 79, 8937) confronts structurally defined barriers: steric …

Metal-hydride hydrogen atom transfer (MHAT) has emerged as a useful tool to form
quaternary carbons from alkenes via hydrofunctionalization. Methods to date that cross …

This review deals with some key synthetic developments based on the use of iron or cobalt
complexes to promote radical reactivity which have been devised over the last decades. We …