Gene-based therapies have emerged as a new modality for combating a myriad of currently
incurable diseases. However, the fragile nature of gene therapeutics has significantly …

Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

Non-viral gene delivery systems are one of the most potential alternatives to viral vectors
because of their less immunogenicity, less toxicity and easy productivity in spite of their low …

Abstract The green tea catechin,(–)-epigallocatechin-3-O-gallate (EGCG), has gained
significant attention as a potent adjuvant to enhance the antitumor efficacy of cisplatin while …

Polymers used for the delivery of nucleic acids (NAs) typically possess ionizable, cationic
moieties enabling their electrostatic interactions with negatively charged NAs and form …

Polycations that are degradable by reduction of disulfide bonds are developed for
applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of …

Metastatic breast cancer is a major cause of cancer-related female mortality worldwide. The
signal transducer and activator of transcription 3 (STAT3) and the chemokine receptor …

Polymeric materials that respond to a variety of endogenous and external stimuli are actively
developed to overcome the main barriers to successful systemic delivery of therapeutic …

Polycations are promising vectors for the delivery of siRNA therapeutics but they often suffer
from toxicity and low in vivo delivery efficacy. This study tests the hypothesis that combining …

The use of small interfering RNA (siRNA) in cancer treatment has been limited by the lack of
effective systemic delivery methods. Although synthetic polycations have been widely …