Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment.
However, the pathogenesis and physiological indications for predicting protrusion …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular …

Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …

Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of
rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients …

OBJECTIVE Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with
rheumatoid arthritis (RA) and osteoarthritis (OA). The objective of this study was to define the …

RA is a chronic, debilitating disease in which articular inflammation and joint destruction are
accompanied by systemic manifestations including anaemia, fatigue and osteoporosis. IL-6 …

The histological and biochemical changes that occur in the extracellular matrix of the
intervertebral disc (IVD) during ageing and degeneration have been investigated …