Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

Histone-modifying systems play fundamental roles in gene regulation and the development
of multicellular organisms. Histone modifications that are enriched at gene regulatory …

Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of
the blood system. Despite their multipotency, MPPs display poorly understood lineage bias …

DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and
operate within distinct genomic compartments. In mammals, the majority of the genome is …

The exploration of three-dimensional chromatin interaction and organization provides
insight into mechanisms underlying gene regulation, cell differentiation and disease …

Due to its excellent performance in processing large amounts of data and capturing complex
non‐linear relationships, deep learning has been widely applied in many fields of plant …

Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in
which signaling pathways such as BMP, TGFβ and WNT are known key players in driving …

Inheritance of 5-methylcytosine from one cell generation to the next by DNA
methyltransferase 1 (DNMT1) plays a key role in regulating cellular identity. While recent …

Motivation Identifying target promoters of active enhancers is a crucial step for realizing
gene regulation and deciphering phenotypes and diseases. Up to now, several …

Alterations in environmentally sensitive epigenetic mechanisms (eg., DNA methylation)
influence axonal regeneration in the spinal cord following sharp injury. Conventional DNA …