The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of
numerous proteins broadly characterized as tumor suppressors, DNA repair proteins …

Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and
play crucial roles in differentiation, proliferation, and cancer. HDAC1 and HDAC2 in …

Neurodegenerative tauopathies characterized by hyperphosphorylated tau include
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and …

Heat shock protein (Hsp) 70 is a molecular chaperone that maintains protein homoeostasis
during cellular stress through two opposing mechanisms: protein refolding and degradation …

Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription
regulation and cell signalling. Highly specific interactions between ubiquitin‐conjugating …

Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as
the disease only becomes symptomatic at an advanced stage. Growing evidence suggests …

During development from the fertilized egg to a multicellular organism, cell fate decisions
have to be taken and cell lineage or tissue-specific gene expression patterns are created …

In this review, I stress the importance of direct data and accurate terminology when
formulating and communicating conclusions on how the G2/M and metaphase/anaphase …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

细胞内所有的蛋白质和大多数的细胞外蛋白都在不断的进行更新, 即它们在不断地被降解,
并被新合成的蛋白质取代. 细胞内蛋白的降解主要通过两个途径, 即自噬和泛素蛋白酶体系统 …