Alginate: current use and future perspectives in pharmaceutical and biomedical applications

M Szekalska, A Puciłowska… - … journal of polymer …, 2016 - Wiley Online Library
Over the last decades, alginates, natural multifunctional polymers, have increasingly drawn
attention as attractive compounds in the biomedical and pharmaceutical fields due to their …

Alginate oligosaccharides: Production, biological activities, and potential applications

J Liu, S Yang, X Li, Q Yan… - … Reviews in Food …, 2019 - Wiley Online Library
Alginate, a group of polyuronic saccharides, has been widely used in both pharmaceutical
and food industries due to its unique physicochemical properties as well as beneficial health …

Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering

N Kohli, V Sharma, A Orera… - Journal of tissue …, 2021 - journals.sagepub.com
Due to the limitations of bone autografts, we aimed to develop new composite biomaterials
with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue …

A universal classification system of skin substitutes inspired by factorial design

E Davison-Kotler, V Sharma, NV Kang… - … Engineering Part B …, 2018 - liebertpub.com
The complexity of the dermal layer of skin means that damage to this section can result in
permanent impairment of function. Partial or total dermal loss is a feature of deep burns and …

In Vitro Evaluation of Scaffolds for the Delivery of Mesenchymal Stem Cells to Wounds

EA Wahl, FA Fierro, TR Peavy… - BioMed Research …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been shown to improve tissue regeneration in
several preclinical and clinical trials. These cells have been used in combination with three …

Poly-ε-caprolactone/fibrin-alginate scaffold: a new pro-angiogenic composite biomaterial for the treatment of bone defects

J Ren, N Kohli, V Sharma, T Shakouri… - Polymers, 2021 - mdpi.com
We hypothesized that a composite of 3D porous melt-electrowritten poly-ɛ-caprolactone
(PCL) coated throughout with a porous and slowly biodegradable fibrin/alginate (FA) matrix …

The importance of factorial design in tissue engineering and biomaterials science: Optimisation of cell seeding efficiency on dermal scaffolds as a case study

A Levin, V Sharma, L Hook… - Journal of Tissue …, 2018 - journals.sagepub.com
This article presents a case study to show the usefulness and importance of using factorial
design in tissue engineering and biomaterials science. We used a full factorial experimental …

Comparison of yield, purity, and functional properties of large-volume exosome isolation using ultrafiltration and polymer-based precipitation

M Gao, J Cai, HS Zitkovsky, B Chen… - Plastic and …, 2022 - journals.lww.com
Background: Mesenchymal stem cell–derived exosomes are known to produce effects
similar to those of source cells and therefore represent a new approach in cell-free …

Viscoelastic, physical, and bio-degradable properties of dermal scaffolds and related cell behaviour

V Sharma, N Patel, N Kohli, N Ravindran… - Biomedical …, 2016 - iopscience.iop.org
Dermal scaffolds promote healing of debilitating skin injuries caused by burns and chronic
skin conditions. Currently available products present disadvantages and therefore, there is …

The bioactivity of composite Fmoc-RGDS-collagen gels

RM Gouveia, RR Jones, IW Hamley… - Biomaterials science, 2014 - pubs.rsc.org
The incorporation of small bioactive peptide motifs within robust hydrogels constitutes a
facile procedure to chemically functionalise cell and tissue scaffolds. In this study, a novel …